Partial syntheses of avermectin Bla and ivermectin from avermectin B2a |
| |
Authors: | H. Mrozik P. Eskola M.H. Fisher |
| |
Affiliation: | Merck Sharp & Dohme Research Laboratories, P. O. Box 2000, Rahway, New Jersey 07065 U.S.A. |
| |
Abstract: | 4″,5-Bis-O-(-butyldimethylsilyloxyacetyl)-23-O-(4-methylphenyloxythiocarbonyl)avermectin B2a gave on pyrolysis and deprotection avermectin Bla, while reduction with tri-n-butyltin hydride followed by deprotection afforded 22,23-dihydroavermectin Bla (ivermectin). |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|