Total synthesis of 5-desoxyleukotriene D. A new and useful equivalent of the 4-formyl-<span class="math"><math><mtext>trans</mtext></math></span>, <span class="math"><math><mtext>trans</mtext></math></span>-1,3-butadienyl anion期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Total synthesis of 5-desoxyleukotriene D. A new and useful equivalent of the 4-formyl- $trans$ , $trans$ -1,3-butadienyl anion

Authors:	E.J. Corey Dennis J. Hoover

Affiliation:	Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138 U.S.A.

Abstract:	The first total synthesis of 5-desoxyleukotriene D ( $14$ ) is reported. The route of synthesis utilizes a novel method for five-carbon chain extension. The availability of $14$ allowed experimental demonstration that the 5-hydroxyl function is important for biological activity of the slow reacting substances.

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