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On the mechanism of the reaction of enamines and dimethyl acetylenedicarboxylate (DMAD) in polar and apolar solvents
Authors:GW Visser  W Verboom  WP Trompenaars  DN Reihoudt
Institution:Twente University of Technology, Enschede, The Netherlands
Abstract:2+2]-Cycloadducts of enamines and DMAD, formed in apolar solvents, isomerize to pyrrolizine derivatives under mild conditions in protic polar solvents like methanol and 1-butanol.
Keywords:
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