2-cyano Δ3 piperidines vi1 : a general method for the stereoselective synthesis of cis and trans 2,6-dialkylpiperidine alkaloids |
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Authors: | Martine Bonin José R Romero David S Grierson Henri-Philippe Husson |
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Affiliation: | Institut de Chimie des Substances Naturelles du C.N.R.S., 91190 Gif s/Yvette France |
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Abstract: | The cis 2,6-dialkylpiperidine alkaloid (±) dihydro-pinidine and the trans alkaloid (±) solenopsin A were synthesized from a common α-aminonitrile synthon . The key step in this synthesis was the stereoselective reductive decyanation of the 1-benzyl-2cyano-2′, 6-dialkylpiperidines and . |
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