A highly efficient and general -monomethylation of functionalized primary amines via formylation--borane:methyl sulfide reduction |
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Authors: | S. Krishnamurthy |
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Affiliation: | Research Laboratories, Eastman Kodak Company, Rochester, New York 14650, U.S.A. |
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Abstract: | Formylation of functionalized primary aromatic and aliphatic amines with acetic formic anhydride (AFA) followed by borane:methyl sulfide reduction in the same pot affords the corresponding -methylamines in excellent isolated yields, uncontaminated bybis alkylation; the reaction sequence is applicable to even very weakly basic and sterically hindered amines. |
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