Chirale synthese von (+)-lycoricidin |
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Authors: | Hans Paulsen Matthias Stubbe |
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Affiliation: | Institut für Organische Chemie und Biochemie der Universität Hamburg D-2000 Hamburg 13, Bundesrepublik Deutschland Germany |
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Abstract: | The synthesis of (+)-lycoricidine from D-glucose is described. Addition of the carbanion to the nitroolefine yields the adduct + , from which crystalline lactone with -configuration in the cyclitol-ring can be isolated after hydrolysis and cyclization. Rearrangement to the lactam and elimination yields the (+)-lycoricidine. |
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