Solvent effects in 5-deazaflavin oxidation as a model for NAD+ dependent enzymes |
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| Authors: | Seiji Shinkai Hideo Kuroda Osamu Manabe |
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| Institution: | Department of Industrial Chemistry, Faculty of Engineering Nagasaki University, Nagasaki 852, Japan |
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| Abstract: | The oxidation rate of 3,5-di-t-butylsalicyl alcohol by 3-methyl-10-ethyl-5-deazaisoalloxazine was found to be very sensitive to solvent effect, the rate constant in 99 vol% DMF being greater by a factor of 37 than that in 50:50 (v/v) DMF-water mixed solvent. The result suggests the importance of the aprotic nature of the reaction environment during the oxidation of alcohols by NAD+. |
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