Synthesis and Antitumor Activity of New Polysubstituted Thiophenes and 1,3,4‐Thiadiazoles Incorporating 2,6‐Pyridine Moieties |
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| Authors: | Korany A Ali Heba S Abdalghfar Khaled Mahmoud Eman A Ragab |
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| Institution: | 1. Applied Organic Chemistry Department, National Research Center, , Cairo, 12622 Egypt;2. Department of Pharmacognosy, National Research Center, , Cairo, 12622 Egypt;3. Chemistry Department, Faculty of Science, University of Cairo, , Cairo, 12613 Egypt |
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| Abstract: | The versatile multifunctional unreported pyridine‐2,6‐bis(2‐cyano‐N‐phenyl‐3‐oxopropanethioamide) ( 3 ) was prepared starting from pyridine‐2,6‐bis‐(3‐oxopropanenitrile) ( 1 ). Several new series of polysubstituted thiophenes and 1,3,4‐thiadiazoles incorporating 2,6‐pyridine moiety were efficiently synthesized. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines: hepatocellular liver carcinoma (HEPG2) and Caucasian breast adenocarcinoma (MCF‐7). Some of the newly synthesized compounds exhibited better activity than doxorubicin as a reference drug. |
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