An Efficient Synthesis and In Vitro Antibacterial Activity of Novel Spiro‐aminopyrimidones |
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| Authors: | Saeed Balalaie Hamid Moghimi Morteza Bararjanian Frank Rominger Hamid Reza Bijanzadeh Masoumeh Sheikhahmadi |
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| Affiliation: | 1. Peptide Chemistry Research Center, K. N. Toosi University of Technology, , Tehran, 15875‐4416 Iran;2. Department of Microbiology, Faculty of Biology, University of Tehran, , Tehran, Iran;3. Organisch Chemisches Institut der Universitaet Heidelberg, , Heidelberg, 69120 Germany;4. Department of Chemistry, Tarbiat Modares University, , Tehran, 141115‐175 Iran |
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| Abstract: | A highly efficient one‐pot synthesis of some new spiro‐2‐aminopyrimidinones via a three‐component reaction of cyclic ketones, methylcyanoacetate or malononitrile, and guanidinium carbonate has been developed through a domino Knoevenagel/Michael/cyclization sequence. The hydrogen bonding capacity of these compounds would make these structures especially stable. Furthermore, the antibacterial study reveals that these types of compounds exhibit good antibacterial activity. |
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