Synthesis,Characterization, and In Vitro Antimicrobial Activity of Methyleneamine‐Linked Bis‐heterocycles |
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| Authors: | A Babulreddy R V Hymavathi Md Manzoor Hussain G Narayana Swamy |
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| Institution: | 1. Department of Molecular Science and Technology, Ajou University, , Suwon, 443‐749 South Korea;2. Department of Chemistry, Sri Krishnadevaraya University, , Anantapur, 515003 Andhra Pradesh, India;3. Department of Bio‐Chemistry, Sri Krishnadevaraya University, , Anantapur, 515003 Andhra Pradesh, India |
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| Abstract: | A new class of methyleneamine‐linked bis‐heterocycles that exhibit antimicrobial activity was synthesized. Bromination of 1 followed by condensation with thiourea gave 3 . The reaction of 3 with propargyl bromide in dry toluene under inert atmosphere led to the formation of 4 . Its subsequent reaction with different nitrile oxides using CuSO4.5H2O–sodiumascorbate system in a 2:1 mixture of water and tert‐butyl alcohol yielded the title compounds 6a , 6b , 6c , 6d , 6e , 6f , 6g , 6h , 6i , 6j , 6k , 6l in good yields. The identities of these compounds were confirmed following elemental analysis, IR, 1H, 13C NMR, and mass spectral studies. All the title compounds exhibited pronounced in vitro antibacterial and antifungal activities. |
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