Some New Pyrazole and Pyrazolopyrimidines: Synthesis and Antimicrobial Evaluation |
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| Authors: | Ahmed H Shamroukh Aymn E Rashad Hatem S Ali Farouk M E Abdel‐Megeid |
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| Institution: | 1. Photochemistry Department, National Research Center, , Cairo, Egypt;2. Chemistry Department, Faculty of Science, Hail University, , Hail, Saudi Arabia;3. Chemistry Department, Faculty of Science and Humanities, Shaqra University, , Shaqra, Huraymila, Saudi Arabia;4. Food Science and Nutrition Department, Faculty of Food Science and Agriculture, King Saud University, , Riyadh, Saudi Arabia |
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| Abstract: | Novel β‐enaminonitrile of 1‐(6‐phenyl‐pyridazin‐3‐yl)‐pyrazole derivative 2 was formed using (6‐phenyl‐pyridazin‐3‐yl)‐hydrazine ( 1 ) and 2‐ethoxymethylene‐malononitrile. The β‐enaminonitrile derivative 2 was in turn used as precursors for the preparation of 1‐(6‐phenyl‐pyridazin‐3‐yl)‐pyrazoles ( 3 , 9 , 11 ), 1‐(6‐phenyl ‐pyridazin‐3‐yl)‐pyrazolo3,4‐d]pyrimidines ( 4 , 5 , 6 , 7 , 8 , 13 , 14 , 15 , 16 ) and some of their corresponding N‐acyclic nucleosides ( 17 , 18 ). All synthesized compounds were tested for their antimicrobial evaluation, and compounds 3 , 9 , 17 , and 18 showed more significant activity than the other tested compounds and some known drugs (standers). |
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