Design and Synthesis of New Imatinib Analogs Containing Thiazolyl Moiety |
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| Authors: | Yu Luo Haiyan Liu Wei Lu |
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| Institution: | 1. Department of Chemistry, East China Normal University, , Shanghai, 200062 China;2. Institute of Drug Discovery and Development, iAIR, East China Normal University, , Shanghai, 200062 China |
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| Abstract: | A series of thiazolyl moiety‐containing pyrimidine derivatives were synthesized and evaluated for their cytotoxicity against chronic myelogenous leukemia cell line K562 and human breast cancer cell line MCF‐7. Most compounds showed good antiproliferation activity. |
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