Rapidly and Highly Yielded Synthesis of Pyrimidine,Dihydropyrimidinone, and Triazino[2,1‐b]quinazolin‐6‐ones Derivatives |
| |
| Authors: | Shaaban K Mohamed Ahmed M Soliman Mahmoud A A El Remaily H Abdel‐Ghany |
| |
| Institution: | 1. School of Biology, Chemistry and Material Science, Manchester Metropolitan University, , Manchester, United Kingdom;2. Department of Chemistry, Sohag University, , Egypt |
| |
| Abstract: | The reaction of 4‐oxo‐3,4‐dihydroquinazolinyl‐2‐guanidine 1 with several active methylene compounds has revealed formation of the corresponding hydropyrimidine and dihydropyrimidnone (DHPMs) derivatives via cycloaddition reaction mechanism. Satisfactory results were obtained with good yields, short time, and simplicity in the experimental procedure. Reaction with ketones in DMF proceeded via (5+1) heterocyclization and resulted in the formation of 2‐amino‐4‐(het)aryl‐4,6‐dihydro‐1(3)(11)H‐1,3,5]triazino2,1‐b]quinazolin‐6‐ones 8 , 9 , 10 , 11 , 12 , 13 , respectively. All compounds have been characterized based on IR, 1H‐NMR, and mass spectrum. |
| |
| Keywords: | |
|
|
