One‐Pot Three‐Component Synthesis of Spirooxindoles Catalyzed by Hexamethylenetetramine in Water |
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| Authors: | Guo‐Dong Wang Xiao‐Nan Zhang Zhan‐Hui Zhang |
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| Institution: | The College of Chemistry & Material Science, Hebei Normal University, , Shijiazhuang, 050024 China |
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| Abstract: | A simple, convenient, and multicomponent strategy for synthesis of spirooxindole derivatives has been developed. This strategy provides a rapid access to construct a diversity‐oriented library of spirooxindoles by using three simple and readily available isatin, malononitrile or cyanoacetic ester, and 1,3‐dicarbonyl compound catalyzed by hexamethylenetetramine in water. |
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