Synthesis of 3,4‐Dihydropyrimidinones via Phase Transfer Catalysis |
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| Authors: | Younes Moussaoui Ridha Ben Salem |
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| Institution: | 1. Science Faculty of Gafsa, Gafsa University, , Zarroug city, Gafsa 2112 Tunisia;2. Science Faculty of Sfax, Sfax University, Physical Organic Chemistry Laboratory, , Sfax, 3018 Tunisia |
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| Abstract: | 3,4‐Dihydropyrimidinone and derivatives were synthesized by the one‐pot, three‐component Biginelli condensation of an aldehyde, β‐dicarbonyl compound and urea. Synthesis was carried out in aqueous sodium hydroxide using Aliquat‐336 as a phase transfer agent. Compared to the classical Biginelli reaction conditions, this new method cousistently has the advantage of excellent yields and short reaction time. |
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