Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Wayne State University, , Detroit, Michigan, 48201
Abstract:
An efficient synthetic method for the preparation of pyridyl‐pyrimidines as potential inhibitors of protein–protein interactions is described. The key transformation is the reaction of a pyrimidine enaminone with phenyl ethyl acetate and NH4OAc to yield the desired pyridyl‐pyrimidine.