|
|||||
|
|
Synthesis of Substituted Pyridyl‐Pyrimidines as Potential Protein–Protein Interaction Inhibitors |
|
| Authors: | Shahid Islam Steven M. Firestine |
| Affiliation: | Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Wayne State University, , Detroit, Michigan, 48201 |
| Abstract: | An efficient synthetic method for the preparation of pyridyl‐pyrimidines as potential inhibitors of protein–protein interactions is described. The key transformation is the reaction of a pyrimidine enaminone with phenyl ethyl acetate and NH4OAc to yield the desired pyridyl‐pyrimidine. |
| Keywords: | pyridyl‐pyrimidines protein‐protein inhibitors medicinal chemistry pyridyl pyrimidines |