1H and 13C NMR investigation of 20‐hydroxyecdysone dioxolane derivatives,a novel group of MDR modulator agents |
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| Authors: | Attila Balázs Attila Hunyadi József Csábi Nikoletta Jedlinszki Ana Martins András Simon Gábor Tóth |
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| Institution: | 1. Ubichem Research Ltd., , H‐1097 Budapest, Hungary;2. Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, , H‐6720 Szeged, Hungary;3. Department of Medical Microbiology and Immunobiology, University of Szeged, , H‐6720 Szeged, Hungary;4. Unidade de Parasitologia e Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, , 1349‐008 Lisbon, Portugal;5. Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, , H‐1111 Budapest, Hungary |
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| Abstract: | The synthesis, structure elucidation and the complete 1H and 13C signal assignment of a series of dioxolane derivatives of 20‐hydroxyecdysone, synthesized as novel modulators of multidrug resistance, are presented. The structures and NMR signal assignment were established by comprehensive one‐dimensional and two‐dimensional NMR spectroscopy supported by mass spectrometry. Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | 1H NMR 13C NMR stereochemistry 20‐hydroxyecdysone dioxolanes antitumor agents P‐glycoprotein |
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