Determination of cyanuric acid using exact matching isotope dilution mass spectrometry |
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Authors: | Guiwan Koh Ee‐mei Gui Tang‐Lin Teo Tong‐Kooi Lee |
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Affiliation: | Health Sciences Authority, Chemical Metrology Division, Chemical Metrology Laboratory, , Singapore |
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Abstract: | A high‐accuracy double isotope dilution mass spectrometric method using an exact matching approach with GC coupled to a mass spectrometer for the analysis of cyanuric acid in fortified milk powder was developed. Various parameters for sample clean‐up such as the type of SPE cartridge, GC column and type of derivatizing agent used were investigated. The method was found to be linear in the concentration range of 0.03 to 2 mg/kg of cyanuric acid in milk powder. LOD and LOQ were found to be 0.9 and 3 μg/kg, respectively. Recoveries in the range of 95.7 to 102.2% were obtained for the in‐house fortified milk powder samples, with RSD of measurements in the range of 0.2 to 3.0%. A metrological approach was undertaken to examine all possible biases that contributed to the combined measurement uncertainty of the method. This high‐accuracy method can serve as a reference method for techniques commonly applied in routine testing laboratories. |
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Keywords: | Isotope dilution MS Cyanuric acid Milk powder |
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