Rapid determination of residual pesticides in tobacco by the quick,easy, cheap,effective, rugged,and safe sample pretreatment method coupled with LC–MS |
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| Authors: | Meilan Li Yan Jin Hai‐Fang Li Yuki Hashi Yuan Ma Jin‐Ming Lin |
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| Affiliation: | 1. Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Tsinghua University, , Beijing, China;2. Yunnan Academy of Tobacco Agricultural Science, , Yuxi, China;3. Shimadzu Corporation, Global COE for Application & Technical Development, , Shanghai, China |
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| Abstract: | A quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample pretreatment method coupled with LC–MS was developed for the determination of 11 pesticides in tobacco. Sample pretreatment parameters and instrumental parameters of LC–MS were investigated, and the optimal conditions were selected. Under the optimized conditions, the 11 pesticides were detected simultaneously with a good linear relationship (r2 = 0.9993–0.9999) and high precisions (less than 5% of the RSD of peak areas). The LODs were in the range of 0.1–5.0 μg/L. Compared with SPE clean‐up, QuEChERS greatly simplified the sample pretreatment with simple solvent extraction system. After QuEChERS pretreatment, no serious matrix effects were observed. Used for the analysis of real samples, metalaxyl was found in cigarette and tobacco samples at 63.47 and 132.27 ng/g, respectively. The recoveries for 11 pesticides were in the range of 70.03–118.69%, and RSDs were less than 10%. The proposed method is simple, low cost, and has good reproducibility. |
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| Keywords: | Liquid chromatography– mass spectrometry Pesticide residues QuEChERS Tobacco |
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