Synthesis of Novel 2‐Amino‐(2‐thioxo‐3‐alkyl‐4‐methyl‐3H‐thiazol‐5‐yl)‐[1,3,4]thiadiazole Derivatives and Their Growth Stimulant Activity |
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Authors: | Aram M. Knyazyan Karine A. Eliazyan Vergush A. Pivazyan Emma A. Ghazaryan Siranush V. Harutyunyan Aleksandr P. Yengoyan |
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Affiliation: | 1. Department of Chemistry, Armenian‐Russian (Slavonic) State University, , Yerevan, Armenia;2. Laboratory of Pesticides Synthesis, Armenian State Agrarian University, , Yerevan, Armenia |
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Abstract: | On the base of synthesized 2‐amino and 2‐ethylamino‐(2‐thioxo‐3‐alkyl‐4‐methyl‐3H‐thiazol‐5‐yl)‐[1,3,4]thiadiazoles, their alkyl, acetyl, and alkylacetylamino derivatives are obtained. The alkylation of 2‐ethylamino derivatives can occur at both exo and endo nitrogen atoms of amidine group, and the acetylation takes place exclusively at the exocyclic nitrogen atom. At acetylation of 2‐amino‐[1,3,4]thiadiazoles, only exo substitution is observed. At the further alkylation of these products, a mixture of exo‐ and endo‐substituted forms is obtained. At preliminary screening, the synthesized compounds have shown expressed growth stimulant properties. The activity of the most active derivatives was in the range of 65–100%, compared with that of heteroauxin. |
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