Novel Synthetic Approach Toward C‐Substituted Piperazine Derivatives via C‐N Bonds Formation of α‐Bromoarylethanones and Ethanolamine |
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| Authors: | Gao Cao Ai‐Xi Hu Yan‐Li Xie Zhen Zhou |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, , Guangzhou 510006, People's Republic of China;2. College of Chemistry and Chemical Engineering, Hunan University, , Changsha 410082, People's Republic of China |
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| Abstract: | A new method for the synthesis of novel C‐substituted piperazine derivatives bearing aryl substituents on 2,6‐C positions has been developed by one‐pot three‐component sequential reaction of α‐bromoarylethanones with ethanolamine in the presence of formic acid. The structure of the novel compounds was established by nuclear magnetic resonance (NMR), mass spectrometry (MS), and elemental analysis. In addition, the crystal structure of 4e was determined by single X‐ray crystallography and a possible reaction mechanism was proposed. |
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