Synthesis and Antitumor Evaluation of Some New Fused and Binary Pyridines |
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| Authors: | Mohamed A Waly Ibrahim I EL‐Hawary Wafaa S Hamama Hanafi H Zoorob |
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| Institution: | 1. Department of Chemistry, Faculty of Science (Damietta), Mansoura University, , Egypt;2. Department of Chemistry, Faculty of Science, Mansoura University, , Mansoura, ET-35516, Egypt |
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| Abstract: | Syntheses of some new heterocyclic compounds containing pyridone, thioxopyridine, halogenated‐pyridine‐carbonitriles, pyrazolopyridine, and pyridine derivatives were achieved. Besides, a modified synthetic method for the synthesis of 2‐chloro‐4,6‐dimethyl‐nicotinonitrile ( 3 ) through the reaction of acetylacetone and malononitrile as starting materials was implemented. The reaction of 2‐chloronicotinonitrile 3 with substituted amines to 2‐aminonicotinonitrile were also investigated. Fused or binary pyridines were tested for cytotoxicity against well‐known established model Ehrlich ascites cells in vitro. Compound 13 exhibited a high antitumor activity compared with 5‐fluorouracil. |
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