Synthesis of Some New Fused and Binary 1,3,4‐Thiadiazoles as Potential Antitumor and Antioxidant Agents |
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Authors: | Wafaa S. Hamama Moustafa A. Gouda Marwa H. Badr Hanafi H. Zoorob |
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Affiliation: | Chemistry Department, Faculty of Science, Mansoura University, , Mansoura, 35516 Egypt |
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Abstract: | Annulations of 2‐amino‐1,3,4‐thiadiazole ( 1 ) with α,β‐unsaturated carbonyl compounds 2 , 5 , and 9 afforded thiadiazolo[3,2‐a]pyrimidin 3 , benzamide 7 , and bis‐pyrazole derivative 11 . Cyclization of benzamide 7 with POCl3 gave binary imidazole derivative 8 . Moreover, alkylation of 1 with 2‐bromo‐1‐(2H‐chromen‐3‐yl) ethanone ( 9 ) followed by cyclization gave imidazo[2,1‐b]‐1,3,4‐thiadiazole derivative 15 . Multicomponent reaction of 1 with heterocyclic and/or aromatic aldehyde and thioglycolic acid afforded the corresponding thiazolidinones 17 and 19 . Finally, a one‐pot synthesis of 1 with isatin and thiosemicarbazide furnished the spirotriazole 20 . The newly synthesized compounds were evaluated as antitumor agents. |
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