Responsive Materials for Self‐Regulated Insulin Delivery |
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| Authors: | Weitai Wu Shuiqin Zhou |
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| Institution: | 1. State Key Laboratory for Physical Chemistry of Solid Surfaces, and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, , Xiamen, 361005 China;2. Department of Chemistry of The College of Staten Island and The Graduate Center, The City University of New York, , Staten Island, New York, 10314 United States |
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| Abstract: | With diabetes mellitus becoming an important public health concern, insulin‐delivery systems are attracting increasing interest from both scientific and technological researchers. This feature article covers the present state‐of‐the‐art glucose‐responsive insulin‐delivery system (denoted as GRIDS), based on responsive polymer materials, a promising system for self‐regulated insulin delivery. Three types of GRIDS are discussed, based on different fundamental mechanisms of glucose‐recognition, with: a) glucose enzyme, b) glucose binding protein, and c) synthetic boronic acid as the glucose‐sensitive component. At the end, a personal perspective on the major issues yet to be worked out in future research is provided. |
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| Keywords: | biological applications of polymers diabetes gels insulin‐delivery systems stimuli‐responsive polymers |
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