Sensitive voltammetric detection of clomipramine at 16-mercapto-hexadecanoic acid self-assembled monolayer modified gold electrode |
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Authors: | Fei Huang Song Qu Song Zhang Baohong Liu Jilie Kong |
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Institution: | (1) Department of Chemistry, Fudan University, Shanghai, P.R. China |
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Abstract: | Clomipramine, an effective and important antipsychotic drug with low redox activity and poor hydrophilicity, was found to
effectively accumulate on hydrophobic 16-mercaptohexadecanoic acid (i.e. MHA) self-assembled monolayer (SAM) modified gold
electrode (i.e. MHA/Au) and generating a sensitive anodic peak at about 0.86 V (vs. SCE) in 0.05 M Tris–HCl (pH = 8.1) buffer
solution. Thus, quantitative measurement of clomipramine was established with high sensitivity under optimum conditions. The
anodic peak current was linear to clomipramine concentration in the range from 1 × 10−6 to 5 × 10−5 M, with a detection limit of 6 × 10−9 M. This method was successfully applied to the detection of clomipramine in drug tablets and proved to be reliable compared
to UV. The spectral features, electrochemical characteristics and wettability of MHA-SAM were also studied.
Correspondence: Jilie Kong, Department of Chemistry, Fudan University, Shanghai 200433, P.R. China |
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Keywords: | : Clomipramine 16-mercaptohexadecanoic acid self-assembled monolayer detection characterization |
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