Microwave‐assisted Friedländer Synthesis of Polysubstituted Quinolines Based on Poly(ethylene glycol) Bound Acetoacetate |
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| Authors: | Xiao‐Liang Zhang Qiao‐Sheng Hu Sheng‐Ri Sheng Chen Xiao Ming‐Zhong Cai |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China;2. College of Chemistry and Life Science, Gannan Normal University, Ganzhou 341000, P. R. China |
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| Abstract: | Polysubstituted quinolines were efficiently prepared on the soluble polyethylene glycol (PEG) by microwave irradiation Friedländer condensation of PEG bound acetoacetate with 2‐aminoarylketones promoted by catalytic amount of polyphosphoric acid, and subsequently cleavage from the PEG with MeONa in MeOH. The polymer‐supported synthesis provided the target compounds in excellent yield and purity with a facile work‐up procedure. |
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| Keywords: | Liquid‐phase synthesis PEG bound acetoacetate 2‐Aminoarylketone Polysubstituted quinoline |
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