Synthesis of 2‐Oxopyridine‐Fused 1,3‐Diazaheterocyclic Compounds via a Three‐Component Reaction |
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| Authors: | Abdolali Alizadeh Azadeh Mikaeili Tahereh Firuzyar Mahdi Ahmadi |
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| Institution: | 1. Department of Chemistry, Tarbiat Modares University, P.?O. Box 14115‐175, Tehran, Iran, (phone: +98‐21‐88006631;2. fax: +98‐21‐88006544) |
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| Abstract: | An efficient and simple route for the preparation of 2‐oxopyridine‐fused 1,3‐diazaheterocyclic compounds via a three component reaction is described. It involves the reaction between alkylenediamines 1 , 1,1‐bis(methylsulfanyl)‐2‐nitroethene, and alkyl prop‐2‐ynoates 2 in refluxing THF (Table). The structures were corroborated by spectroscopic (IR, 1H‐ and 13C‐NMR, and EI‐MS) and elemental analyses. A plausible mechanism for this type of cyclization is proposed (Scheme). |
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| Keywords: | 1 3‐Diazaheterocycles Pyridin‐2‐one Multicomponent reactions |
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