Three New Diterpenoids from Isodon nervosus |
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| Authors: | Zhi‐Xiong Wei You‐Heng Gao Fen Yang Hai‐Xiao Lu Lin Ni Xiao‐Hong Zhou |
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| Institution: | Department of Phytochemistry, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.?R. China, (phone: +86‐20‐39358083) |
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| Abstract: | Three new ent‐kaurane diterpenoids, rabdonervosins D–F ( 1 – 3 ), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated on the basis of spectroscopic methods including 1D‐ and 2D‐NMR analyses. Compounds 1 – 3 were evaluated for their cytotoxicity against HepG2, CNE2, PC‐9/ZD, HeLa, MCF‐7, and HCT116 cell lines. No compounds exhibited potent cytotoxicity. |
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| Keywords: | Isodon nervosus Diterpenoids Rabdonervosins D – F Cytotoxic activity |
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