An efficient one‐pot synthesis of dispiropyrrolidine derivatives through 1,3‐dipolar cycloaddition reactions under ultrasound irradiation |
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| Authors: | Hai Liu Yi Zou Yu Hu Da‐Qing Shi |
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| Affiliation: | 1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China;2. School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, People's Republic of China |
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| Abstract: | A series of dispiropyrrolidine derivatives were synthesized via the three‐component 1,3‐dipolar cycloaddition reaction of isatin, sarcosine and 5‐arylidene‐1,3‐thiazolidine‐2,4‐dione or 5‐arylidene‐4‐thioxo‐1,3‐thiazolidine‐2‐one in ethanol under ultrasound irradiation. This protocol has the advantages of mild reaction conditions, higher yields, and shorter reaction time. J. Heterocyclic Chem., (2011). |
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