Synthesis and conversion of 6‐fluoro derivatives of 1,3,4‐thiadiazolo‐[3,2‐a]pyrimidine |
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| Authors: | Muhamadsho A Kukaniev Cyril Párkányi |
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| Institution: | 1. Laboratory of Chemistry of Heterocyclic Compounds, V.I.Nikitin Institute of Chemistry of the Academy of Sciences of the Republic of Tajikistan, 299/2 Ainy St., 734063 Dushanbe, Tajikistan;2. Department of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, P.O. Box 3091, Boca Raton, Florida 33431‐0991 |
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| Abstract: | 2‐Alkyl‐, 2‐aryl‐, and 2‐halo‐substituted derivatives of 7‐methyl‐6‐fluoro‐1,3,4‐thiadiazolo3,2‐a]pyrimidin‐6‐one ( 3 ) were prepared by reaction of 2‐substituted 5‐amino‐1,3,4‐thiadiazoles ( 1 ) and ethyl 2‐fluoroacetoacetate ( 2 ) in polyphosphoric acid. A convenient procedure was developed for the synthesis of new 2‐amino derivatives of 2‐R‐7‐methyl‐6‐fluoro‐1,3,4‐thiadiazolo3,2‐a]pyrimidin‐6‐one ( 5 ). J. Heterocyclic Chem., (2011). |
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