Convertible Fluorous Sulfonate Linker for the Synthesis of Diverse Library Scaffolds |
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Authors: | Asha Kadam Shan Ding Bruno Piqani Wei Zhang |
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Institution: | Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA |
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Abstract: | Aryl perfluorooctanesulfonates (fluorous sulfonate) have been developed as triflates and nonaflates alternatives for Pd‐catalyzed coupling reactions to form C‐C, C‐N, C‐S, C‐H, and C‐CN bonds. They also serve as phase‐tags for fluorous solid‐phase extraction (F‐SPE) to facilitate product purifications. Other synthetic techniques such as microwave reactions and multicomponent reactions are combined with the fluorous linker strategy to further increase synthetic efficiency. The utility of fluorous sulfonate linkers in the synthesis of biologically interested library scaffolds is summarized in this short review article. |
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Keywords: | Perfluorooctanesulfonates Fluorous benzaldehydes Microwave reactions Multicomponent reactions Fluorous solid‐phase extraction Heterocyclic scaffolds |
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