One‐step synthesis of 2,4,5‐trisubstituted pyrimidines |
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| Authors: | Chuang‐Jun Zhang Wen‐Yong Han Mi‐Xiang Gao Fei‐Fei Xu Zun‐Ting Zhang |
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| Affiliation: | Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, and School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, People's Republic of China |
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| Abstract: | A simple and straightforward methodology towards the synthesis of 2,4,5‐trisubstituted pyrimidines has been developed by one‐step reaction of isoflavones with thiourea or guanidine. Ten 2‐mercapto‐4,5‐diphenylpyrimidines and eight 2‐amino‐4,5‐diphenylpyrimidines were reported. All of them were characterized by FT‐IR, NMR, and elemental analysis. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery. J. Heterocyclic Chem., (2011). |
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