Submicro methods for the analysis of organic compounds : The determination of acetyl groups |
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Authors: | A.K. Awasthy K. Belcher A.M.G. Macdonald |
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Affiliation: | Department of Chemistry, The University, Birmingham15 Great Britain |
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Abstract: | Methods are described for the determination of O-acetyl and N-acetyl groups in 30–80-μg samples of organic compounds. The best general method involved hydrolysis with Wenzel sulphuric acid and distillation of the acetic acid formed, in a small apparatus of the wiesenberger type, followed by visual acid-base titration. The overall recovery was 99.1% and the average relative accuracy was ± 2.5% ; accuracy and precision were slightly less satisfactory for alkaline hydrolysis or hydrolysis with phosphoric acid. |
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