New Cytochalasins from the Marine‐Derived Fungus Xylaria sp. SCSIO 156 |
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| Authors: | Ziming Chen Hongbo Huang Yuchan Chen Zhongwen Wang Junying Ma Bo Wang Weimin Zhang Changsheng Zhang Jianhua Ju |
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| Institution: | 1. CAS Key Laboratory of Marine Bio‐resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, P.?R. China, (phone/fax: +86‐20‐8209‐3028);2. Graduate School of the Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, P.?R. China;3. Guangdong Institute of Microbiology, 100 Central Xianlie Road, Guangzhou 510070, P.?R. China |
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| Abstract: | Two new cytochalasins, 18‐deoxycytochalasin Q ( 1 ) and 21‐O‐deacetylcytochalasin Q ( 2 ), together with four known analogues, cytochalasin Q ( 3 ), 19,20‐epoxycytochalasin Q ( 4 ), 21‐O‐deacetyl‐19,20‐epoxycytochalasin Q ( 5 ), and cytochalasin D ( 6 ), were isolated from the fungus Xylaria sp. SCSIO156 originated from the South China Sea marine sediment. The structures of 1 and 2 were elucidated by MS and 1D‐ and 2D‐NMR data analyses, and comparison with known compounds. The known compounds 3 – 6 were identified by comparison of their MS and NMR data with those reported in the literature. In the in vitro antitumor assay, compounds 2 – 6 showed mild cytotoxicity against three tumor cell lines (MCF‐7, SF‐268, and NCI‐H460). |
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| Keywords: | Xylaria species Fungi Cytochalasins Cytotoxic activity |
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