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Two New Cytotoxic Alkaloids from Mappianthus iodoides Hand.‐Mazz.
Authors:Xi‐Bin Xiao  Yue‐Xing Lin  Geng‐Bo Xu  Xu‐Bo Gong  Ying Gu  Jie‐Feng Tong  Jing Yang
Institution:1. Department of Hematology, Second Affiliated Hospital, Zhejiang University, No.?88 Jiefang Road, Hangzhou 310009, P.?R. China (phone: +86‐571‐87783652);2. Blood Bank, Second Affiliated Hospital, Zhejiang University, Hangzhou 310009, P.?R. China
Abstract:Two new alkaloids, mappine A ( 1 ) and mapposidic acid ( 2 ), together with eleven known compounds, were isolated from the stems of Mappianthus iodoides Hand.‐Mazz. Their structures were elucidated by means of spectroscopic and mass‐spectrometric analyses, particularly 1D‐ and 2D‐NMR spectroscopy. The cytotoxic activities of the two new alkaloids were also evaluated.
Keywords:Mappianthus iodoides  Alkaloids  Mappine A  Mapposidic acid  Cytotoxic activity
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