Synthesis and Reactions of 1‐Amino‐5‐morpholin‐4‐yl‐6,7,8,9‐tetrahydrothieno[2,3‐c]isoquinoline |
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| Authors: | Remon M. Zaki Shaban M. Radwan Adel M. Kamal El‐Dean |
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| Affiliation: | Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt |
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| Abstract: | The pyrazolone derivative 4 was synthesized by reaction of carbohydrazide 2 with ethyl benzoylacetate in ethanol and p‐toluene sulphonic acid followed by cyclization upon heating in acetic acid. Chloroacylation of amino ester and amino benzoyl compounds 1 , 19 gave the chloro acetylamino derivatives 5 and 20 respectively which both of them react with different amines to afford compounds 6 , 23a‐d . Hydrolysis and decarboxlation of compound 1 yielded the aminothienotetrahydroisoquinoline 8 which was used as versatile material for synthesizing other heterocyclic compounds 9‐18 . Compound 20 react with hexamethylenetetramine and malononitrile yielded thediazepino and pyrrolo derivatives 21 , 22 respectively. |
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