Anthracene and Anthraquinone Derivatives from the Stem Bark of Juglans mandshurica Maxim. |
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| Authors: | Li‐Hua Zheng Xiang‐Ying Meng Yong‐Li Bao Yin Wu Chun‐Lei Yu Yan‐Xin Huang Yu‐Xin Li |
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| Institution: | 1. National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, ChangChun 130024, P.?R. China, (phone: +86‐431‐85099502;2. fax: +86‐431‐85099502);3. Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Renmin Street 5268, ChangChun 130024, P.?R. China;4. Institute of Genetics and Cytology, Northeast Normal University, Renmin Street 5268, ChangChun 130024, P.?R. China |
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| Abstract: | One new anthracene derivative, juglanthracenoside A ( 1 ), two new anthraquinones, juglanthraquinone A ( 2 ) and juglanthraquinone B ( 3 ), along with a new naturally occurring anthraquinone, 9,10‐dihydro‐4,8‐dihydroxy‐9,10‐dioxoanthracene‐2‐carboxylic acid ( 4 ), have been isolated from the stem bark of Juglans mandshurica. Their structures were established by detailed spectroscopic analysis and comparison of the NMR data with those of related compounds. Compound 1 displayed noticeable antioxidant activity in both 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) free radical‐scavenging assays, while compound 4 showed strong cytotoxicity against HepG2, SGC7901, HCT‐8, and A549 cell lines in vitro. |
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| Keywords: | Juglans mandshurica Juglanthracenoside A Juglanthraquinones A and B Antioxidant activity Cytotoxic activity Anthracenes Anthraquinones |
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