An intramolecular N‐arylation approach to 3‐functionalized 4,9‐dihydropyrrolo[2,1‐b]quinazolines |
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| Authors: | Nisaraporn Suthiwangcharoen Steven M Pochini Daniel P Sweat Chad E Stephens |
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| Institution: | Department of Chemistry and Physics, Augusta State University, Augusta, Georgia 30904 |
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| Abstract: | A series of 4,9‐dihydropyrrolo2,1‐b]quinazolines containing electron withdrawing groups at the 3‐position have been prepared by the palladium‐catalyzed intramolecular N‐arylation of some 2‐aminopyrroles having a 2‐bromobenzyl group at the N‐1 position. Important for success of the reaction is the use of X‐phos, a biphenyl mono‐phosphine ligand, instead of xantphos, a more standard diphosphine ligand, and the use of t‐BuOH as reaction solvent. J. Heterocyclic Chem., (2011). |
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