|
|||||
|
|
Total Synthesis of (−)‐Cleistenolide |
|
| Authors: | Dokuburra Chanti?Babu Kankati Ashalatha Chitturi Bhujanga Rao Jon Paul Selvam Jondoss Yenamandra Venkateswarlu |
| Institution: | 1. Natural Products Laboratory, Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Hyderabad‐500007, India (phone: +91‐40‐27193167;2. fax: +91‐40‐27160512) |
| Abstract: | An efficient and short total synthesis of (?)‐cleistenolide ( 1 ) from D ‐mannitol with an overall yield of 23.6% is described. The chiron approach for the synthesis of (?)‐cleistenolide involves a one‐C‐atom Wittig olefination, a selective allylic triethylsilyl protection, and a Grubbs‐catalyzed ring‐closure‐metathesis (RCM) reaction as the key steps. |
| Keywords: | Cleistochlamys kirkii (− )‐Cleistenolide Wittig reaction Ring‐closing metathesis (RCM) |