1. Natural Products Laboratory, Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Hyderabad‐500007, India (phone: +91‐40‐27193167;2. fax: +91‐40‐27160512)
Abstract:
An efficient and short total synthesis of (?)‐cleistenolide ( 1 ) from D ‐mannitol with an overall yield of 23.6% is described. The chiron approach for the synthesis of (?)‐cleistenolide involves a one‐C‐atom Wittig olefination, a selective allylic triethylsilyl protection, and a Grubbs‐catalyzed ring‐closure‐metathesis (RCM) reaction as the key steps.