Synthesis and antitumor activity of new 1,2,4‐triazine and [1,2,4]triazolo[4,3‐b][1,2,4]triazine derivatives and their thioglycoside and acyclic C‐nucleoside analogs |
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| Authors: | Wael A. El‐Sayed Ibrahim F. Nassar Adel A.‐H. Abdel‐Rahman |
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| Affiliation: | 1. Department of Photochemistry, National Research Centre, Cairo, Egypt;2. Faculty of Education, Ain Shams University, Abbassia, Cairo, Egypt;3. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El‐Koam, Egypt |
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| Abstract: | New 1,2,4‐triazine and their derived 1,2,4‐triazolo[3,4‐b][1,2,4]triazine derivatives were synthesized starting from 5,6‐diphenyl‐1,2,4‐triazine‐3‐thiol. Furthermore, the corresponding 1,2,4‐triazolo[3,4‐b][1,2,4]‐triazine thioglycosides and acyclic C‐nucleoside analogs were synthesized. The newly synthesized compounds were evaluated for their antitumor activity and some of them showed high inhibition activities. J. Heterocyclic Chem., 2011. |
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