On-line sample preparation for high throughput reversed-phase LC/MS analysis of combinatorial chemistry libraries |
| |
Authors: | Tang L Fitch W L Smith P Tumelty D Cao K Ferla S W |
| |
Institution: | Affymax Research Institute, 4001 Miranda Avenue, Palo Alto, CA 94304, USA. ltang@tularik.com |
| |
Abstract: | An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography/mass spectrometry (LC/MS). This approach is particularly helpful for the LC/MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|