| 竹红菌乙素镁、锌配位聚合物的光物理和光生物性质 |
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| 引用本文： | 郭创龙,欧植泽,高云燕,王中丽,金和林,李海霞. 竹红菌乙素镁、锌配位聚合物的光物理和光生物性质[J]. 物理化学学报, 2011, 27(11): 2682-2690. DOI: 10.3866/PKU.WHXB20111132 |
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| 作者姓名： | 郭创龙 欧植泽 高云燕 王中丽 金和林 李海霞 |
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| 作者单位： | Key Laboratory of Space, Applied Physics and Chemistry, Ministry of Education, School of Science, Northwestern Polytechnical University, Xi'an 710072 |
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| 基金项目： | 国家自然科学基金，教育部"春晖计划"基金，西北工业大学基础研究基金 |
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| 摘 要： | 竹红菌乙素(HB)能与Mg2+和Zn2+形成重复单元数为5-20的配位聚合物(Mg2+-HB,Zn2+-HB),利用紫外-可见(UV-Vis)吸收光谱,傅里叶变换红外(FTIR)光谱,核磁共振氢谱(1H NMR)对其进行了表征.Mg2+-HB和Zn2+-HB的单重态氧量子产率分别为HB的1.2倍和0.42倍.瞬态吸收实验表明:氧气能够猝灭Mg2+-HB和Zn2+-HB的三重态,其效率可超过96％.系间窜越效率(φT)和将能量传递给氧气并能产生单重态氧的三重态光敏剂的比例(fT△)对HB及其金属配合物的单重态氧量子产率有较大影响.电子自旋共振(EPR)实验结果表明:Mg2+-HB和Zn2+-HB产生半醌负离子自由基的能力较弱,进而降低了Mg2+-HB和Zn2+-HB光敏产生超氧负离子自由基的能力.紫外-可见吸收光谱与小牛胸腺脱氧核糖核酸(CT DNA)熔链温度实验表明:Mg2+-HB和Zn2+-HB可通过静电作用与DNA结合.有氧条件下,Mg2+-HB,HB和Zn2+-HB对小牛胸腺DNA的光敏损伤效率分别为32％,25％和22％.活性氧猝灭实验表明Mg2+-HB主要通过单重态氧光敏损伤DNA.
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| 关 键 词： | 竹红菌乙素 配位聚合物 单重态氧 超氧负离子自由基 DNA光损伤 |
| 收稿时间： | 2011-07-19 |
| 修稿时间： | 2011-09-20 |
Photophysical and Photobiological Properties of Coordination Polymers of Hypocrellin B Complexes Containing Magnesium and Zinc |
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| GUO Chuang-Long,OU Zhi-Ze,GAO Yun-Yan,WANG Zhong-Li,JIN He-Lin,LI Hai-Xia. Photophysical and Photobiological Properties of Coordination Polymers of Hypocrellin B Complexes Containing Magnesium and Zinc[J]. Acta Physico-Chimica Sinica, 2011, 27(11): 2682-2690. DOI: 10.3866/PKU.WHXB20111132 |
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| Authors: | GUO Chuang-Long OU Zhi-Ze GAO Yun-Yan WANG Zhong-Li JIN He-Lin LI Hai-Xia |
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| Affiliation: | Key Laboratory of Space, Applied Physics and Chemistry, Ministry of Education, School of Science, Northwestern Polytechnical University, Xi'an 710072 |
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| Abstract: | Hypocrellin B(HB) can chelate with Mg~(2+) and Zn~(2+) ions to form the coordination complexes Mg~(2+)-HB and Zn~(2+)-HB,which consist of 5-22 repeat units.The structures of these two complexes are characterized by ultraviolet-visible(UV-Vis) spectroscopy,Fourier transform infrared(FTIR) spectroscopy, and ~1H nuclear magnetic resonance(~1H NMR).The relative quantum yields of singlet oxygen(~1O_2) for Mg~(2+)-HB and Zn~(2+)-HB are 1.2 and 0.42 times as high as that of HB,respectively.Transient absorption spe... |
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| Keywords: | Hypocrellin B Coordination polymer Singlet oxygen Superoxide anion radical DNA photodamage |
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