Chemistry and Chemical Engineering School, Henan University of Technology, Zhengzhou 450001, China
Abstract:
An efficient palladium-catalyzed copper- and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new ligand. The use of 2 mol % Pd(OAc)2 in the presence of K2CO3 allows the coupling reaction to proceed at mild condition with good to excellent yields.