Facile one-pot synthesis of pyrido[2,3-d]pyrimidine derivatives over ZrO2 nanoparticles catalyst |
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Authors: | Shahrzad Abdolmohammadi Maryam Afsharpour |
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Institution: | Department of Chemistry, East Tehran Branch, Islamic Azad University, PO Box 33955-163, Tehran, Iran ; Nano Science and Technology Research Center, University of Tehran, Tehran, Iran |
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Abstract: | An efficient synthesis of hexahydropyrido2,3-d]pyrimidinetrione derivatives is achieved via tandem Knoevenagel-Michael addition of aromatic aldehydes, methylcyanoacetate and 4(6)-aminouracil in solvent-free conditions in the presence of 10 mol% of ZrO2 nanoparticles (ZrO2 NPs) as a heterogeneous catalyst. The procedure is formed in high yields, short reaction time and an environmentally friendly specificity. |
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Keywords: | Pyrido[2 3-d]pyrimidines Solvent-free Tandem Knoevenagel-Michael addition " target="_blank">2 nanoparticleszz')" href="#"> ZrO2 nanoparticles |
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