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Intramolecular copper(I)-catalyzed 1,3-dipolar cycloaddition of azido-alkynes: synthesis of triazolo-benzoxazepine derivatives and their biological evaluation |
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| Authors: | Srivari Chandrasekhar Mallikanti SeenaiahAbhishek Kumar Chada Raji ReddySuman Kumar Mamidyala Chityal Ganesh KumarSridhar Balasubramanian |
| Institution: | a Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India b Chemical Biology Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India c Center for X-ray Crystallography, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | Synthesis of a series of 1,2,3] triazolo 5,1-c] 1,4]benzoxazepine derivatives have been accomplished by the intramolecular Cu(I)-catalyzed cycloaddition of azido-alkynes derived from salicylaldehyde. The biological profile of these heterocyclic structural scaffolds toward anti-bacterial as well as anti-fungal activity has also been illustrated. |
| Keywords: | 1 3-Dipolar cycloaddition Copper-catalysis Triazolo-benzoxazepine Anti-microbial Click chemistry |
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