Direct electrochemical regeneration of monooxygenase subunits for biocatalytic asymmetric epoxidation |
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| Authors: | Hollmann Frank Hofstetter Karin Habicher Tilo Hauer Bernhard Schmid Andreas |
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| Affiliation: | Institute for Biotechnology, Swiss Federal Institute of Technology, Zurich, Switzerland, BASF Aktiengesellschaft, Ludwigshafen, Germany. |
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| Abstract: | We report the first example of direct electrochemical regeneration of a flavin-dependent monooxygenase for asymmetric epoxidation catalysis. It is shown that electrochemical regeneration of the oxygenase subunit of the multicomponent styrene monooxygenase is sufficient to perform enantiospecific S-epoxidation of various styrene derivatives. Kinetic bottlenecks of the novel electroenzymatic reaction are identified. This work opens up new alternatives for asymmetric oxyfunctionalization catalysis. |
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