| Study on the Aggregation and Deaggregation Behaviors of Phosphatidylcholines |
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| 作者姓名： | 计国桢 龙亚秋 蒋锡夔 |
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| 作者单位： | ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences,Shanghai200032,China |
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| 基金项目： | National Natural Science Foundation of China(No.29392201). |
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| 摘 要： | Phosphatdylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological processes and exhibit a broad range of desirable pharmacological effects, which involve hydrophobic lipophilic interactions (HLI) between the phospholipid and the cell membrane. The HLI behavior of phosphatJdylcholines (Ln) and their analogues 1, 2-diacyl-sn-glycerol-3-phosphoric acid bromoethyl ester (Pn), have been investigated in MeOH-H20 binary systems of different volume fractions (designated as Φ) of the organic component, by employing α-nephthylethyl lauryl ether (Np-12) as fluorescent probe. A very interesting observation is that the Ln possesses double character, i. e., it behaves both as an aggregator and as a deaggregator. The effects of the structure and the environment on the coaggregation and deaggregtion are also discussed.
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| 关 键 词： | 卵磷脂 解聚行为 聚合行为 疏水亲油性 生理学 药理效应 细胞膜 |
Study on the Aggregation and Deaggregation Behaviors of Phos-phatidylcholines |
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| JI,Guo-Zhen LONG,Ya-Qiu JIANG,Xi-Kui.Study on the Aggregation and Deaggregation Behaviors of Phosphatidylcholines[J].Chinese Journal of Chemistry,2003,21(7):731-738. |
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| Authors: | JI Guo-Zhen LONG Ya-Qiu JIANG Xi-Kui |
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| Institution: | JI,Guo-Zhen LONG,Ya-Qiu JIANG,Xi-Kui
Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China |
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| Abstract: | Phosphatidylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological processes and exhibit a broad range of desirable pharmacological effects, which involve hydrophobic lipophilic interactions (HLI) between the phospholipid and the cell membrane. The HLI behavior of phosphatidylcholines (Ln) and their analogues 1, 2‐diacyl‐sn‐glycerol‐3‐phosphoric acid bromoethyl ester (Pn), have been investigated in MeOH‐H2O binary systems of different volume fractions (designated as ?) of the organic component, by employing α‐nephthylethyl lauryl ether (Np‐12) as fluorescent probe. A very interesting observation is that the Ln possesses double character, i.e., it behaves both as an aggregator and as a deaggregator. The effects of the structure and the environment on the coaggregation and deaggregation are also discussed. |
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| Keywords: | phosphatidylcholine hydrophobic lipophilic interac-tions (HLI) aggregation deaggregation |
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