Redox and electrocatalytic properties of mimochrome VI, a synthetic heme peptide adsorbed on gold |
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Authors: | Ranieri Antonio Monari Stefano Sola Marco Borsari Marco Battistuzzi Gianantonio Ringhieri Paola Nastri Flavia Pavone Vincenzo Lombardi Angelina |
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Affiliation: | Department of Chemistry, University of Modena and Reggio Emilia, via Campi 183, 41125 Modena, Italy. |
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Abstract: | Mimochrome VI (MC-VI) is a synthetic heme peptide containing a helix-heme-helix sandwich motif designed to reproduce the catalytic activity of heme oxidases. The thermodynamics of Fe(III) to Fe(II) reduction and the kinetics of the electron-transfer process for MC-VI immobilized through hydrophobic interactions on a gold electrode coated with a nonpolar SAM of decane-1-thiol have been determined through cyclic voltammetry. Immobilization slightly affects the reduction potential of MC-VI, which under these conditions electrocatalytically turns over molecular oxygen. This work sets the premise for the exploitation of totally synthetic mimochrome-modified electrode surfaces for clinical and pharmaceutical biosensing. |
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