| Synthesis of Cholest-5-en-24-oxo-3b, 19-Diacetate |
| |
| 作者姓名： | Wei Gang LU Ming Yan WANG Jing Yu SU Long Mei ZENG* School of Chemistry and Chemical Engineering Zhongshan University Guangzhou |
| |
| 作者单位： | Wei Gang LU，Ming Yan WANG，Jing Yu SU，Long Mei ZENG* School of Chemistry and Chemical Engineering，Zhongshan University，Guangzhou 510275 |
| |
| 基金项目： | We are grateful to the National Natural Science Foundation of China (No. 29932030) and Natural Science Foundation (No. 970154) of Guangdong Province for financial support for this work. |
| |
| 摘 要： | Two biologically active 19-hydroxylated sterols, 24-methylenecholesta-3b, 5a, 6b, 19- tetrol 1, 24-methylenecholesta-5-ene-3b, 7b, 19-triol 2, were isolated from the soft corals, Nephthea albida and Nepthea tiexieral verseveldt by L. M. Zeng1,2. 1 showed strong anti-inflamatory activity comparable with dexamethone and 2 showed potent anti-leukemic activity (IC50 0.01 mg/mL). We have designed a synthetic route for the synthesis of 1 and 2 as shown in Scheme 1. In this route, cholest-5-en-…
|
Synthesis of Cholest-5-en-24-oxo-3b, 19-Diacetate |
| |
| Wei Gang LU,Ming Yan WANG,Jing Yu SU,Long Mei ZENG* School of Chemistry and Chemical Engineering,Zhongshan University,Guangzhou .Synthesis of Cholest-5-en-24-oxo-3b, 19-Diacetate[J].Chinese Chemical Letters,2002,13(2). |
| |
| Authors: | Wei Gang LU Ming Yan WANG Jing Yu SU Long Mei ZENG |
| |
| Abstract: | Cholest-5-en-24-oxo-3, 19-diacetate was synthesized starting from stigmasterol 3 via seven step reactions in 21.0% overall yield. It can be served as a key intermediate for the synthesis of many biologically active 19-hydroxylated sterols. |
| |
| Keywords: | Hydroxylated sterol synthesis irradiation ozonolization |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
