Application
of DSC and NIRS to study the compatibility of metronidazole with different
pharmaceutical excipients |
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| Authors: | D Kiss R Zelkó Cs Novák Zs Éhen |
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| Institution: | (1) University Pharmacy, Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary, 1092, Hőgyes E. u. 7–9;(2) Research Group of Technical Analytical Chemistry, Hungarian Academy of Sciences, Budapest University of Technology and Economics, Budapest, Hungary, 1111, Szt. Gellért tér 4;(3) Institute of General and Analytical Chemistry, University of Technology and Economics, Budapest, Hungary, 1111, Szt. Gellért tér 4 |
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| Abstract: | The purpose of the present
work was to study the compatibility of metronidazole with different pharmaceutical
excipients (hydroxypropyl methylcellulose, poly(ethylene oxide), microcrystalline
cellulose, dicalcium phosphate dihydrate, and anhydrous dicalcium phosphate)
using differential scanning calorimetry and diffuse reflectance spectroscopy.
Dicalcium phosphate dihydrate was the only excipient that showed interaction
with metronidazole even before storage. Changes referring to a possible transition
to dihydrate form were observed in the thermal curves of anhydrous dicalcium
phosphate after four weeks of storage. Although dicalcium phosphate dihydrate
can be replaced by the anhydrous form in pharmaceutical formulations, the
observed transition might negatively influence the stability of dosage forms. |
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| Keywords: | anhydrous dicalcium phosphate compatibility dicalcium phosphate dihydrate DSC metronidazole NIRS |
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